Nano materials-based devices by photodynamic therapy for treating cancer applications

  • Sargol Mazraedoost Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Gity Behbudi Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Keywords: Photodynamic Therapy (PDT), Cancer, Nanotechnology, Drug Delivery Systems


      Photodynamic therapy (PDT) is a non-invasive beneficial modality that is able to be used instead of radiotherapy and chemotherapy to treat cancer. Low water solubility makes administering photosensitizers (PSs) complicated, which undermines several molecules' medicinal application, limits PDT's efficacy. Nanotechnology can be used to tune the photoactive drug's pharmacokinetics and tumor selectivity and perform a vital role in the photosensitizer's photodynamic function by maintaining the photosensitizer's monomeric structure and thereby optimizing the photochemistry that occurs upon photon absorption. Also, nanotechnology-based drug delivery systems may progress a PS's transcytosis by allowing two or different drugs to be delivered at the same time via epithelial and endothelial barriers. Based on this, nanotechnology's application in medicine could open up a slew of novel cancer treatment possibilities while also improving the efficacy of presently available medicines. Consequently, this research aims to investigate nanotechnology-based medication conveyance instruments utilized for photodynamic cancer treatment.


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