The role of Nanoparticles for Reactive Oxygen Species (ROS) in Biomedical Engineering
Among the greatest varied and cross-cutting features of biomedical nanotechnology applications is the synthesis, design, and characterization of novel nanomaterials. New developments in synthetics and engineering make it possible to produce an extensive variety of nanoparticles (NPs) and biocompatible nanostructured materials widely used in efficient diagnosis, drug delivery, and therapeutic procedures or deprived of other chemical and/or surface modifications of biomolecules. Because of their physical and chemical properties, metal-based nanoparticles (MNPs), as well as quantum dots (QDs), magnetic NPs, metal NPs, and metal oxide NPs, have a tremendous amount of power for biomedical applications. Nanoparticles (NPs) have superior (chemical and physical) features that create an ideal for different usages. Metallic NPs' structural modifications result in various biological activities, leading to diverse development capacities for reactive oxygen species (ROS). With chemistry, size, surface area, and particle shape, the amount of ROS provided by metallic NPs are correlated. In cell biology, ROS has many functions. ROS generation is a critical component in the toxicity caused by metallic NP and cellular signaling in cell differentiation, proliferation, and death.
1. Bayda, S., et al., The history of nanoscience and nanotechnology: From chemical–physical applications to nanomedicine. Molecules, 2020. 25(1): p. 112.
2. Jeevanandam, J., et al., Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations. Beilstein journal of nanotechnology, 2018. 9(1): p. 1050-1074.
3. Mazraedoost, S. and G. Behbudi, Basic Nano Magnetic Particles and Essential Oils: Biological Applications. Journal of Environmental Treatment Techniques, 2021. 9(3): p. 609-620.
4. Mazraedoost, S. and G. Behbudi, Nano materials-based devices by photodynamic therapy for treating cancer applications. Advances in Applied NanoBio-Technologies, 2021. 2(3): p. 9-21.
5. Masoumzade, R., G. Behbudi, and S. Mazraedoost, A medical encyclopedia with new approach graphene quantum dots for anti-breast cancer applications: mini review. Advances in Applied NanoBio-Technologies, 2020. 1(4): p. 84-90.
6. Mousavi, S.M., et al., Data on cytotoxic and antibacterial activity of synthesized Fe3O4 nanoparticles using Malva sylvestris. Data in brief, 2020. 28: p. 104929.
7. Goudarzian, N., et al., Enhancing the Physical, Mechanical, Oxygen Permeability and Photodegradation Properties of Styrene-acrylonitrile (SAN), Butadiene Rubber (BR) Composite by Silica Nanoparticles. Journal of Environmental Treatment Techniques, 2020. 8(2): p. 718-726.
8. Tech, J.E.T., Investigating the Activity of Antioxidants Activities Content in Apiaceae and to Study Antimicrobial and Insecticidal Activity of Antioxidant by using SPME Fiber Assembly Carboxen/Polydimethylsiloxane (CAR/PDMS). Journal of Environmental Treatment Techniques, 2020. 8(1): p. 214-24.
9. Bruchez, M., et al., Semiconductor nanocrystals as fluorescent biological labels. science, 1998. 281(5385): p. 2013-2016.
10. Wang, S., et al., Antigen/antibody immunocomplex from CdTe nanoparticle bioconjugates. Nano letters, 2002. 2(8): p. 817-822.
11. Ma, J., et al., Biomimetic processing of nanocrystallite bioactive apatite coating on titanium. Nanotechnology, 2003. 14(6): p. 619.
12. Nam, J.-M., C.S. Thaxton, and C.A. Mirkin, Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. science, 2003. 301(5641): p. 1884-1886.
13. Edelstein, R., et al., The BARC biosensor applied to the detection of biological warfare agents. Biosensors and Bioelectronics, 2000. 14(10-11): p. 805-813.
14. Mahtab, R., J.P. Rogers, and C.J. Murphy, Protein-sized quantum dot luminescence can distinguish between" straight"," bent", and" kinked" oligonucleotides. Journal of the American Chemical Society, 1995. 117(35): p. 9099-9100.
15. Molday, R.S. and D. Mackenzie, Immunospecific ferromagnetic iron-dextran reagents for the labeling and magnetic separation of cells. Journal of immunological methods, 1982. 52(3): p. 353-367.
16. Shen, Z., A. Wu, and X. Chen, Iron oxide nanoparticle based contrast agents for magnetic resonance imaging. Molecular pharmaceutics, 2017. 14(5): p. 1352-1364.
17. Gordon, R., Encyclopedia of Biophysics. 2013.
18. Jin, S. and K. Ye, Nanoparticle‐mediated drug delivery and gene therapy. Biotechnology progress, 2007. 23(1): p. 32-41.
19. Gholami, A., et al., 3D nanostructures for tissue engineering, cancer therapy, and gene delivery. Journal of Nanomaterials, 2020. 2020.
20. Jaque, D., et al., Nanoparticles for photothermal therapies. nanoscale, 2014. 6(16): p. 9494-9530.
21. Zhang, Y., et al., Enhancement of HIFU ablation by sonosensitizer-loading liquid fluorocarbon nanoparticles with pre-targeting in a mouse model. Scientific reports, 2019. 9(1): p. 1-18.
22. Bosca, F., et al., Exploiting Lipid and Polymer Nanocarriers to Improve the Anticancer Sonodynamic Activity of Chlorophyll. Pharmaceutics, 2020. 12(7): p. 605.
23. Brazzale, C., et al., Enhanced selective sonosensitizing efficacy of ultrasound-based anticancer treatment by targeted gold nanoparticles. Nanomedicine, 2016. 12(23): p. 3053-3070.
24. Foglietta, F., et al., Sonodynamic treatment as an innovative bimodal anticancer approach: shock wave-mediated tumor growth inhibition in a syngeneic breast cancer model. 2015.
25. Varchi, G., et al., Engineered porphyrin loaded core-shell nanoparticles for selective sonodynamic anticancer treatment. Nanomedicine, 2015. 10(23): p. 3483-3494.
26. Abrahamse, H., et al., Nanoparticles for advanced photodynamic therapy of cancer. Photomedicine and laser surgery, 2017. 35(11): p. 581-588.
27. Abrahamse, H. and M.R. Hamblin, New photosensitizers for photodynamic therapy. Biochemical Journal, 2016. 473(4): p. 347-364.
28. Sortino, S., Light-responsive nanostructured systems for applications in nanomedicine. 2016: Springer.
29. Abdal Dayem, A., et al., The role of reactive oxygen species (ROS) in the biological activities of metallic nanoparticles. International journal of molecular sciences, 2017. 18(1): p. 120.
30. Ciccarese, F., et al., Nanoparticles as tools to target redox homeostasis in cancer cells. Antioxidants, 2020. 9(3): p. 211.
31. Canaparo, R., et al., Biomedical Applications of Reactive Oxygen Species Generation by Metal Nanoparticles. Materials, 2021. 14(1): p. 53.
32. Mousavi, S.M., et al., Development of graphene based nanocomposites towards medical and biological applications. Artificial cells, nanomedicine, and biotechnology, 2020. 48(1): p. 1189-1205.
33. Mousavi, S.M., et al., Nanosensors for chemical and biological and medical applications. Med Chem (Los Angeles), 2018. 8(8): p. 2161-0444.1000515.
34. Hashemi, S.A., et al., Coupled graphene oxide with hybrid metallic nanoparticles as potential electrochemical biosensors for precise detection of ascorbic acid within blood. Analytica chimica acta, 2020. 1107: p. 183-192.
35. Bahrani, S., et al., Zinc-based metal–organic frameworks as nontoxic and biodegradable platforms for biomedical applications: review study. Drug metabolism reviews, 2019. 51(3): p. 356-377.
36. Mousavi, M., et al., Erythrosine adsorption from aqueous solution via decorated graphene oxide with magnetic iron oxide nano particles: kinetic and equilibrium studies. Acta Chimica Slovenica, 2018. 65(4): p. 882-894.
37. Avval, Z.M., et al., Introduction of magnetic and supermagnetic nanoparticles in new approach of targeting drug delivery and cancer therapy application. Drug metabolism reviews, 2020. 52(1): p. 157-184.
38. Mousavi, S.M., et al., Gold nanostars-diagnosis, bioimaging and biomedical applications. Drug metabolism reviews, 2020. 52(2): p. 299-318.
39. Mousavi, S.M., et al., Carbon Substrates for Flexible Supercapacitors and Energy Storage Applications. Flexible Supercapacitor Nanoarchitectonics, 2021: p. 95-141.
40. Raeisi, F., et al., Application of biosurfactant as a demulsifying and emulsifying agent in the formulation of petrochemical products, in Green Sustainable Process for Chemical and Environmental Engineering and Science. 2021, Elsevier. p. 399-422.
41. Mousavi, S.M., et al., Development of hydrophobic reduced graphene oxide as a new efficient approach for photochemotherapy. RSC Advances, 2020. 10(22): p. 12851-12863.
42. Mousavi, S.M., et al., Recent Advancements in Polythiophene-Based Materials and their Biomedical, Geno Sensor and DNA Detection. International Journal of Molecular Sciences, 2021. 22(13): p. 6850.
43. Mousavi, S.M., et al., Recent Progress in Electrochemical Detection of Human Papillomavirus (HPV) via Graphene-Based Nanosensors. Journal of Sensors, 2021. 2021.
44. Mousavi, S.M., et al., Asymmetric membranes: a potential scaffold for wound healing applications. Symmetry, 2020. 12(7): p. 1100.
45. Hashemi, S.A., et al., Picomolar-level detection of mercury within non-biological/biological aqueous media using ultra-sensitive polyaniline-Fe 3 O 4-silver diethyldithiocarbamate nanostructure. Analytical and Bioanalytical Chemistry, 2020. 412: p. 5353-5365.
46. Hashemi, S.A., et al., Polythiophene silver bromide nanostructure as ultra-sensitive non-enzymatic electrochemical glucose biosensor. European Polymer Journal, 2020. 138: p. 109959.
47. Ahmadi, S., et al., Anti-bacterial/fungal and anti-cancer performance of green synthesized Ag nanoparticles using summer savory extract. Journal of Experimental Nanoscience, 2020. 15(1): p. 363-380.
48. Hashemi, S.A., et al., Integrated polyaniline with graphene oxide-iron tungsten nitride nanoflakes as ultrasensitive electrochemical sensor for precise detection of 4-nitrophenol within aquatic media. Journal of Electroanalytical Chemistry, 2020. 873: p. 114406.
49. Hashemi, S.A., et al., Superior X-ray radiation shielding effectiveness of biocompatible polyaniline reinforced with hybrid graphene oxide-iron tungsten nitride flakes. Polymers, 2020. 12(6): p. 1407.
50. Mousavi, S.M., et al., Green synthesis of supermagnetic Fe3O4–MgO nanoparticles via Nutmeg essential oil toward superior anti-bacterial and anti-fungal performance. Journal of Drug Delivery Science and Technology, 2019. 54: p. 101352.
51. Nel, A., et al., Toxic potential of materials at the nanolevel. science, 2006. 311(5761): p. 622-627.
52. Xia, T., et al., Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS nano, 2008. 2(10): p. 2121-2134.
53. Zhu, X., et al., Biosensing approaches for rapid genotoxicity and cytotoxicity assays upon nanomaterial exposure. Small, 2013. 9(9‐10): p. 1821-1830.
54. Gonzalez, L., D. Lison, and M. Kirsch-Volders, Genotoxicity of engineered nanomaterials: A critical review. Nanotoxicology, 2008. 2(4): p. 252-273.
55. Oberdörster, G., E. Oberdörster, and J. Oberdörster, Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113: 823–839. 2005.
56. Li, Y., et al., Chronic Al2O3-nanoparticle exposure causes neurotoxic effects on locomotion behaviors by inducing severe ROS production and disruption of ROS defense mechanisms in nematode Caenorhabditis elegans. Journal of hazardous materials, 2012. 219: p. 221-230.
57. Winnik, F.M. and D. Maysinger, Quantum dot cytotoxicity and ways to reduce it. Accounts of chemical research, 2013. 46(3): p. 672-680.
58. Akhtar, M.J., et al., Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells. Toxicology, 2010. 276(2): p. 95-102.
59. Akhtar, M.J., et al., Protective effect of sulphoraphane against oxidative stress mediated toxicity induced by CuO nanoparticles in mouse embryonic fibroblasts BALB 3T3. The Journal of toxicological sciences, 2012. 37(1): p. 139-148.
60. Fan, Z. and J.G. Lu, Zinc oxide nanostructures: synthesis and properties. Journal of nanoscience and nanotechnology, 2005. 5(10): p. 1561-1573.
61. Chiang, H.-m., et al., Nanoscale ZnO induces cytotoxicity and DNA damage in human cell lines and rat primary neuronal cells. Journal of nanoscience and nanotechnology, 2012. 12(3): p. 2126-2135.
62. Yin, J.-J., et al., Electron spin resonance spectroscopy for studying the generation and scavenging of reactive oxygen species by nanomaterials, in Nanopharmaceutics: The Potential Application of Nanomaterials. 2013, World Scientific. p. 375-400.
63. Yin, J.-J., et al., Phototoxicity of nano titanium dioxides in HaCaT keratinocytes—generation of reactive oxygen species and cell damage. Toxicology and applied pharmacology, 2012. 263(1): p. 81-88.
64. Applerot, G., et al., Enhanced antibacterial activity of nanocrystalline ZnO due to increased ROS‐mediated cell injury. Advanced Functional Materials, 2009. 19(6): p. 842-852.
65. Wang, J.J., B.J. Sanderson, and H. Wang, Cyto-and genotoxicity of ultrafine TiO2 particles in cultured human lymphoblastoid cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2007. 628(2): p. 99-106.
66. Girgis, E., et al., Nanotoxicity of gold and gold–cobalt nanoalloy. Chemical research in toxicology, 2012. 25(5): p. 1086-1098.
67. Hsin, Y.-H., et al., The apoptotic effect of nanosilver is mediated by a ROS-and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. Toxicology letters, 2008. 179(3): p. 130-139.
68. Kim, S. and D.Y. Ryu, Silver nanoparticle‐induced oxidative stress, genotoxicity and apoptosis in cultured cells and animal tissues. Journal of applied toxicology, 2013. 33(2): p. 78-89.
69. Shvedova, A., et al., Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. Journal of toxicology and environmental health Part A, 2003. 66(20): p. 1909-1926.
70. Liu, Y., et al., Plastic protein microarray to investigate the molecular pathways of magnetic nanoparticle-induced nanotoxicity. Nanotechnology, 2013. 24(17): p. 175501.
71. Wang, Y., et al., A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells. Science of the total environment, 2011. 409(22): p. 4753-4762.
72. Knaapen, A.M., et al., Inhaled particles and lung cancer. Part A: Mechanisms. International Journal of Cancer, 2004. 109(6): p. 799-809.
73. Fu, P.P., et al., Mechanisms of nanotoxicity: generation of reactive oxygen species. Journal of food and drug analysis, 2014. 22(1): p. 64-75.
74. Manke, A., L. Wang, and Y. Rojanasakul, Mechanisms of nanoparticle-induced oxidative stress and toxicity. BioMed research international, 2013. 2013.
75. Vallyathan, V. and X. Shi, The role of oxygen free radicals in occupational and environmental lung diseases. Environmental Health Perspectives, 1997. 105(suppl 1): p. 165-177.
76. Thannickal, V.J. and B.L. Fanburg, Reactive oxygen species in cell signaling. American Journal of Physiology-Lung Cellular and Molecular Physiology, 2000. 279(6): p. L1005-L1028.
77. Maryanovich, M. and A. Gross, A ROS rheostat for cell fate regulation. Trends in cell biology, 2013. 23(3): p. 129-134.
78. Sena, L.A. and N.S. Chandel, Physiological roles of mitochondrial reactive oxygen species. Molecular cell, 2012. 48(2): p. 158-167.
79. Cremers, C.M. and U. Jakob, Oxidant sensing by reversible disulfide bond formation. Journal of Biological Chemistry, 2013. 288(37): p. 26489-26496.
80. Snezhkina, A.V., et al., ROS generation and antioxidant defense systems in normal and malignant cells. Oxidative medicine and cellular longevity, 2019. 2019.
81. Riley, P., Free radicals in biology: oxidative stress and the effects of ionizing radiation. International journal of radiation biology, 1994. 65(1): p. 27-33.
82. Birben, E., et al., Oxidative stress and antioxidant defense. World Allergy Organization Journal, 2012. 5(1): p. 9-19.
83. Poljsak, B., D. Šuput, and I. Milisav, Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants. Oxidative medicine and cellular longevity, 2013. 2013.
84. Forrester, S.J., et al., Reactive oxygen species in metabolic and inflammatory signaling. Circulation research, 2018. 122(6): p. 877-902.
85. Dunyaporn, T., et al., Redox regulation of cell survival. Antioxid Redox Signal, 2008. 10(8): p. p1343-1374.
86. Bae, Y.S., et al., Regulation of reactive oxygen species generation in cell signaling. Molecules and cells, 2011. 32(6): p. 491-509.
87. Valko, M., et al., Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-biological interactions, 2006. 160(1): p. 1-40.
88. Touyz, R.M., Molecular and cellular mechanisms in vascular injury in hypertension: role of angiotensin II–editorial review. Current opinion in nephrology and hypertension, 2005. 14(2): p. 125-131.
89. Mueller, C., Laude K, McNally JS, Harrison DG. ATVB in focus: redox mechanisms in blood vessels. Arterioscler Thromb Vasc Biol, 2005. 25: p. 274-278.
90. Wu, H., et al., Reactive oxygen species-related activities of nano-iron metal and nano-iron oxides. Journal of Food and Drug Analysis, 2014. 22(1): p. 86-94.
91. Halliwell, B., Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. Plant physiology, 2006. 141(2): p. 312-322.
92. Johnson, F. and C. Giulivi, Superoxide dismutases and their impact upon human health. Molecular aspects of medicine, 2005. 26(4-5): p. 340-352.
93. Paravicini, T.M. and R.M. Touyz, NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes care, 2008. 31(Supplement 2): p. S170-S180.
94. Brand, M.D., The sites and topology of mitochondrial superoxide production. Experimental gerontology, 2010. 45(7-8): p. 466-472.
95. Halliwell, B., M.V. Clement, and L.H. Long, Hydrogen peroxide in the human body. FEBS letters, 2000. 486(1): p. 10-13.
96. Hampton, M.B. and S. Orrenius, Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS letters, 1997. 414(3): p. 552-556.
97. Ray, P.D., B.-W. Huang, and Y. Tsuji, Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cellular signalling, 2012. 24(5): p. 981-990.
98. Guzik, T.J. and D.G. Harrison, Vascular NADPH oxidases as drug targets for novel antioxidant strategies. Drug discovery today, 2006. 11(11-12): p. 524-533.
99. Coso, S., et al., NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts. Antioxidants & redox signaling, 2012. 16(11): p. 1229-1247.
100. Bedard, K. and K.-H. Krause, The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiological reviews, 2007. 87(1): p. 245-313.
101. Storz, P., Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxidants & redox signaling, 2011. 14(4): p. 593-605.
102. Salata, O.V., Applications of nanoparticles in biology and medicine. Journal of nanobiotechnology, 2004. 2(1): p. 1-6.
103. Brar, S.K., et al., Engineered nanoparticles in wastewater and wastewater sludge–Evidence and impacts. Waste management, 2010. 30(3): p. 504-520.
104. Ray, P.C., H. Yu, and P.P. Fu, Nanogold-based sensing of environmental toxins: excitement and challenges. Journal of Environmental Science and Health, Part C, 2011. 29(1): p. 52-89.
105. Poljak-Blaži, M., M. Jaganjac, and N. Žarković, Cell oxidative stress: risk of metal nanoparticles. Handbook of Nanophysics Nanomedicine and Nanorobotics, 2010: p. 16-1-16-17.
106. Röcker, C., et al., A quantitative fluorescence study of protein monolayer formation on colloidal nanoparticles. Nature nanotechnology, 2009. 4(9): p. 577-580.
107. Jiang, X., et al., Quantitative analysis of the protein corona on FePt nanoparticles formed by transferrin binding. Journal of The Royal Society Interface, 2010. 7(suppl_1): p. S5-S13.
108. Lynch, I. and K.A. Dawson, Protein-nanoparticle interactions. Nano today, 2008. 3(1-2): p. 40-47.
109. Li, N., T. Xia, and A.E. Nel, The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free radical biology and medicine, 2008. 44(9): p. 1689-1699.
110. Stone, V., H. Johnston, and M.J. Clift, Air pollution, ultrafine and nanoparticle toxicology: cellular and molecular interactions. IEEE transactions on nanobioscience, 2007. 6(4): p. 331-340.
111. Shvedova, A.A., et al., Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress. Toxicology and applied pharmacology, 2012. 261(2): p. 121-133.
112. Zhang, Z., et al., On the interactions of free radicals with gold nanoparticles. Journal of the American Chemical Society, 2003. 125(26): p. 7959-7963.
113. Kennedy, I.M., D. Wilson, and A.I. Barakat, Uptake and inflammatory effects of nanoparticles in a human vascular endothelial cell line. Research Report (Health Effects Institute), 2009(136): p. 3-32.
114. Devarajan, P.V. and S. Jain, Targeted drug delivery: concepts and design. 2015: Springer.
115. Huang, Y.-W., C.-h. Wu, and R.S. Aronstam, Toxicity of transition metal oxide nanoparticles: recent insights from in vitro studies. Materials, 2010. 3(10): p. 4842-4859.
116. Fubini, B. and A. Hubbard, Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radical Biology and Medicine, 2003. 34(12): p. 1507-1516.
117. Trachootham, D., J. Alexandre, and P. Huang, Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nature reviews Drug discovery, 2009. 8(7): p. 579-591.
118. Finkel, T., Signal transduction by mitochondrial oxidants. Journal of Biological Chemistry, 2012. 287(7): p. 4434-4440.
119. Dikalov, S., Cross talk between mitochondria and NADPH oxidases. Free Radical Biology and Medicine, 2011. 51(7): p. 1289-1301.
120. Tahara, E.B., F.D. Navarete, and A.J. Kowaltowski, Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation. Free Radical Biology and Medicine, 2009. 46(9): p. 1283-1297.
121. Okado-Matsumoto, A. and I. Fridovich, Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu, Zn-SOD in mitochondria. Journal of Biological Chemistry, 2001. 276(42): p. 38388-38393.
122. Murphy, M.P., How mitochondria produce reactive oxygen species. Biochemical journal, 2009. 417(1): p. 1-13.
123. Finkel, T., Signal transduction by reactive oxygen species. Journal of Cell Biology, 2011. 194(1): p. 7-15.
124. MacFie, T.S., et al., DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid. Inflammatory bowel diseases, 2014. 20(3): p. 514-524.
125. Yoshihara, A., et al., Regulation of dual oxidase expression and H2O2 production by thyroglobulin. Thyroid, 2012. 22(10): p. 1054-1062.
126. van der Vlies, D., et al., Oxidation of ER resident proteins upon oxidative stress: effects of altering cellular redox/antioxidant status and implications for protein maturation. Antioxidants and redox signaling, 2003. 5(4): p. 381-387.
127. Yasmin, W., K.D. Strynadka, and R. Schulz, Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts. Cardiovascular research, 1997. 33(2): p. 422-432.
128. Halliwell, B. and J.M. Gutteridge, Reactive species can be useful: some more examples, in Free Radicals in Biology and Medicine. 2015, Oxford University Press.
129. Mignolet-Spruyt, L., et al., Spreading the news: subcellular and organellar reactive oxygen species production and signalling. Journal of experimental botany, 2016. 67(13): p. 3831-3844.
130. Risom, L., P. Møller, and S. Loft, Oxidative stress-induced DNA damage by particulate air pollution. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2005. 592(1-2): p. 119-137.
131. Bonner, J.C., Lung fibrotic responses to particle exposure. Toxicologic pathology, 2007. 35(1): p. 148-153.
132. Ray, P.C., H. Yu, and P.P. Fu, Toxicity and environmental risks of nanomaterials: challenges and future needs. Journal of Environmental Science and Health Part C, 2009. 27(1): p. 1-35.
133. Wang, S., et al., Challenge in understanding size and shape dependent toxicity of gold nanomaterials in human skin keratinocytes. Chemical physics letters, 2008. 463(1-3): p. 145-149.
134. Shaligram, S. and A. Campbell, Toxicity of copper salts is dependent on solubility profile and cell type tested. Toxicology in Vitro, 2013. 27(2): p. 844-851.
135. Lu, W., et al., Effect of surface coating on the toxicity of silver nanomaterials on human skin keratinocytes. Chemical physics letters, 2010. 487(1-3): p. 92-96.
136. Wilson, M.R., et al., Interactions between ultrafine particles and transition metals in vivo and in vitro. Toxicology and applied pharmacology, 2002. 184(3): p. 172-179.
137. Sioutas, C., R.J. Delfino, and M. Singh, Exposure assessment for atmospheric ultrafine particles (UFPs) and implications in epidemiologic research. Environmental health perspectives, 2005. 113(8): p. 947-955.
138. Stone, V., et al., The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function. Toxicology in vitro, 1998. 12(6): p. 649-659.
139. Fan, J., et al., Direct evidence for catalase and peroxidase activities of ferritin–platinum nanoparticles. Biomaterials, 2011. 32(6): p. 1611-1618.
140. Donaldson, K. and C.L. Tran, Inflammation caused by particles and fibers. Inhalation toxicology, 2002. 14(1): p. 5-27.
141. Oberdörster, G., et al., Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Particle and fibre toxicology, 2005. 2(1): p. 1-35.
142. Schins, R.P., Mechanisms of genotoxicity of particles and fibers. Inhalation toxicology, 2002. 14(1): p. 57-78.
143. Buzea, C., I.I. Pacheco, and K. Robbie, Nanomaterials and nanoparticles: sources and toxicity. Biointerphases, 2007. 2(4): p. MR17-MR71.
144. Aust, S., et al., Free radicals in toxicology. Toxicology and applied pharmacology, 1993. 120(2): p. 168-178.
145. Mousavi, S.M., et al., Precise Blood Glucose Sensing by Nitrogen-Doped Graphene Quantum Dots for Tight Control of Diabetes. Journal of Sensors, 2021. 2021.
146. Fang, G.-D., D.-M. Zhou, and D.D. Dionysiou, Superoxide mediated production of hydroxyl radicals by magnetite nanoparticles: demonstration in the degradation of 2-chlorobiphenyl. Journal of Hazardous Materials, 2013. 250: p. 68-75.
147. Roduner, E., Size matters: why nanomaterials are different. Chemical Society Reviews, 2006. 35(7): p. 583-592.
148. Yaghini, E., et al. Reactive oxygen species generation from photoexcited quantum dot nanoparticles: Type I versus type II photochemical mechanism. 2011. 13th International Photodynamic Association (IPA) World Congress.
149. Mousavi, S.M., et al., Multifunctional Gold Nanorod for Therapeutic Applications and Pharmaceutical Delivery Considering Cellular Metabolic Responses, Oxidative Stress and Cellular Longevity. Nanomaterials, 2021. 11(7): p. 1868.
150. Sharma, P., et al., Reactive oxygen species, oxidative damage, and antioxidative defense mechanism in plants under stressful conditions. Journal of botany, 2012. 2012.
151. Iversen, T.-G., T. Skotland, and K. Sandvig, Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies. Nano today, 2011. 6(2): p. 176-185.
152. Canton, I. and G. Battaglia, Endocytosis at the nanoscale. Chemical Society Reviews, 2012. 41(7): p. 2718-2739.
153. Smith, K.R., L.R. Klei, and A. Barchowsky, Arsenite stimulates plasma membrane NADPH oxidase in vascular endothelial cells. American Journal of Physiology-Lung Cellular and Molecular Physiology, 2001. 280(3): p. L442-L449.
154. Xia, T., et al., Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano letters, 2006. 6(8): p. 1794-1807.
155. AshaRani, P., Low Kah Mun G, Hande MP, Valiyaveettil S. Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano, 2009. 3(2): p. 279-290.
156. Rahman, K., Studies on free radicals, antioxidants, and co-factors. Clinical interventions in aging, 2007. 2(2): p. 219.
157. Fenoglio, I., et al., The oxidation of glutathione by cobalt/tungsten carbide contributes to hard metal-induced oxidative stress. Free radical research, 2008. 42(8): p. 437-745.
158. Zhang, H., et al., Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS nano, 2012. 6(5): p. 4349-4368.
159. Xu, Q., et al., Reactive oxygen species (ROS) responsive polymers for biomedical applications. Macromolecular bioscience, 2016. 16(5): p. 635-646.
160. Tapeinos, C. and A. Pandit, Physical, chemical, and biological structures based on ROS‐sensitive moieties that are able to respond to oxidative microenvironments. Advanced Materials, 2016. 28(27): p. 5553-5585.
161. Syama, S., et al., Zinc oxide nanoparticles induced oxidative stress in mouse bone marrow mesenchymal stem cells. Toxicology mechanisms and methods, 2014. 24(9): p. 644-653.
162. He, W., et al., Silver nanoparticle based coatings enhance adipogenesis compared to osteogenesis in human mesenchymal stem cells through oxidative stress. Journal of Materials Chemistry B, 2016. 4(8): p. 1466-1479.
163. Celardo, I., et al., Ce3+ ions determine redox-dependent anti-apoptotic effect of cerium oxide nanoparticles. ACS nano, 2011. 5(6): p. 4537-4549.
164. Heckert, E.G., et al., The role of cerium redox state in the SOD mimetic activity of nanoceria. Biomaterials, 2008. 29(18): p. 2705-2709.
165. Celardo, I., E. Traversa, and L. Ghibelli, Cerium oxide nanoparticles: a promise for applications in therapy. J Exp Ther Oncol, 2011. 9(1): p. 47-51.
166. Karakoti, A.S., et al., Preparation and characterization challenges to understanding environmental and biological impacts of ceria nanoparticles. Surface and Interface Analysis, 2012. 44(8): p. 882-889.
167. Bhushan, B. and P. Gopinath, Antioxidant nanozyme: a facile synthesis and evaluation of the reactive oxygen species scavenging potential of nanoceria encapsulated albumin nanoparticles. Journal of Materials Chemistry B, 2015. 3(24): p. 4843-4852.
168. Rocca, A., et al., Cerium oxide nanoparticles inhibit adipogenesis in rat mesenchymal stem cells: potential therapeutic implications. Pharmaceutical research, 2014. 31(11): p. 2952-2962.
169. Pongrac, I.M., et al., Oxidative stress response in neural stem cells exposed to different superparamagnetic iron oxide nanoparticles. International journal of nanomedicine, 2016. 11: p. 1701.
170. Rajanahalli, P., C. Stucke, and Y. Hong, The effects of silver nanoparticles on mouse embryonic stem cell self-renewal and proliferation, Toxicol. Rep. 2 (2015) 758–764.