Carbon Quantum Dots Platforms: as nano therapeutic for Biomedical Applications

  • Masoomeh Yari Kalashgrani university of mohaghegh ardabili
  • Fatemeh Fallahi Nejad
  • Vahid Rahmanian
Keywords: Carbon quantum dots; Biomedical application; Drug delivery; Bioimaging; Biosensor

Abstract

Quantum dots (QDs) have been widely used as bioimaging agents for fluorescent nanoscopes. However, QD can have toxic side effects because it contains heavy metals. Therefore, many researchers have proposed an alternative material with low toxicity and good biocompatibility called carbon quantum dots (CQD). CQDs have many attractive properties due to their structure such as optical properties, photoluminescence and phosphorescence. These exceptional properties can be used for biomedical applications, especially in the fields of drug delivery, bioimaging, and biosensor. This article provides a comprehensive review of CQDs. The primary focus is on their unique properties and toxicity as they relate to the recently reported field of biomedicine and applications.

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References

1. Gordon, A.T., et al., Introduction to nanotechnology: potential applications in physical medicine and rehabilitation. American journal of physical medicine & rehabilitation, 2007. 86(3): p. 225-241.
2. Adams, F.C. and C. Barbante, Nanoscience, nanotechnology and spectrometry. Spectrochimica Acta Part B: Atomic Spectroscopy, 2013. 86: p. 3-13.
3. Tech, J.E.T., Investigating the activity of antioxidants activities content in Apiaceae and to study antimicrobial and insecticidal activity of antioxidant by using SPME Fiber assembly carboxen/polydimethylsiloxane (CAR/PDMS). Journal of Environmental Treatment Techniques, 2020. 8(1): p. 214-24.
4. Alipour, A. and M.Y. Kalashgarani, Nano Protein and Peptides for Drug Delivery and Anticancer Agents. Advances in Applied NanoBio-Technologies, 2022. 3(1): p. 60-64.
5. Rossetti, R. and L. Brus, Electron-hole recombination emission as a probe of surface chemistry in aqueous cadmium sulfide colloids. The Journal of Physical Chemistry, 1982. 86(23): p. 4470-4472.
6. Alivisatos, A.P., Perspectives on the physical chemistry of semiconductor nanocrystals. The Journal of Physical Chemistry, 1996. 100(31): p. 13226-13239.
7. Mousavi, S.M., et al., Recent biotechnological approaches for treatment of novel COVID-19: from bench to clinical trial. Drug Metabolism Reviews, 2021. 53(1): p. 141-170.
8. Ahmadi, S., et al., Green synthesis of magnetic nanoparticles using Satureja hortensis essential oil toward superior antibacterial/fungal and anticancer performance. BioMed Research International, 2021. 2021.
9. Kalashgarani, M.Y. and A. Babapoor, Application of nano-antibiotics in the diagnosis and treatment of infectious diseases. Advances in Applied NanoBio-Technologies, 2022. 3(1): p. 22-35.
10. Poliandri, A.H., et al., Cadmium induces apoptosis in anterior pituitary cells that can be reversed by treatment with antioxidants. Toxicology and Applied Pharmacology, 2003. 190(1): p. 17-24.
11. Geys, J., et al., Acute toxicity and prothrombotic effects of quantum dots: impact of surface charge. Environmental health perspectives, 2008. 116(12): p. 1607-1613.
12. Hosseini, H. and S.M. Mousavi, Bacterial cellulose/polyaniline nanocomposite aerogels as novel bioadsorbents for removal of hexavalent chromium: Experimental and simulation study. Journal of Cleaner Production, 2021. 278: p. 123817.
13. Mousavi, S.M., et al., Bioactive Graphene Quantum Dots Based Polymer Composite for Biomedical Applications. Polymers, 2022. 14(3): p. 617.
14. Wilson, W.L., P. Szajowski, and L. Brus, Quantum confinement in size-selected, surface-oxidized silicon nanocrystals. Science, 1993. 262(5137): p. 1242-1244.
15. Hashemi, S.A., et al., Superior X-ray radiation shielding effectiveness of biocompatible polyaniline reinforced with hybrid graphene oxide-iron tungsten nitride flakes. Polymers, 2020. 12(6): p. 1407.
16. Kazemi, K., Y. Ghahramani, and M.Y. Kalashgrani, Nano biofilms: An emerging biotechnology applications. Advances in Applied NanoBio-Technologies, 2022: p. 8-15.
17. Wolkin, M., et al., Electronic states and luminescence in porous silicon quantum dots: the role of oxygen. Physical Review Letters, 1999. 82(1): p. 197.
18. Hashemi, S.A., et al., Reinforced polypyrrole with 2D graphene flakes decorated with interconnected nickel-tungsten metal oxide complex toward superiorly stable supercapacitor. Chemical Engineering Journal, 2021. 418: p. 129396.
19. Mousavi, S.M., et al., Recent Advances in Plasma-Engineered Polymers for Biomarker-Based Viral Detection and Highly Multiplexed Analysis. Biosensors, 2022. 12(5): p. 286.
20. Li, X., et al., Preparation of carbon quantum dots with tunable photoluminescence by rapid laser passivation in ordinary organic solvents. Chemical Communications, 2010. 47(3): p. 932-934.
21. Mousavi, S.M., et al., Development of graphene based nanocomposites towards medical and biological applications. Artificial cells, nanomedicine, and biotechnology, 2020. 48(1): p. 1189-1205.
22. Lim, S.Y., W. Shen, and Z. Gao, Carbon quantum dots and their applications. Chemical Society Reviews, 2015. 44(1): p. 362-381.
23. Baker, S.N. and G.A. Baker, Luminescent carbon nanodots: emergent nanolights. Angewandte Chemie International Edition, 2010. 49(38): p. 6726-6744.
24. Ahmadi, S., et al., Anti-bacterial/fungal and anti-cancer performance of green synthesized Ag nanoparticles using summer savory extract. Journal of Experimental Nanoscience, 2020. 15(1): p. 363-380.
25. Mousavi, S.M., et al., Plasma-Enabled Smart Nanoexosome Platform as Emerging Immunopathogenesis for Clinical Viral Infection. Pharmaceutics, 2022. 14(5): p. 1054.
26. Wang, Y. and A. Hu, Carbon quantum dots: synthesis, properties and applications. Journal of Materials Chemistry C, 2014. 2(34): p. 6921-6939.
27. Mousavi, S.M., et al., Recent progress in chemical composition, production, and pharmaceutical effects of kombucha beverage: a complementary and alternative medicine. Evidence-Based Complementary and Alternative Medicine, 2020. 2020.
28. Wang, X., et al., Bandgap‐like strong fluorescence in functionalized carbon nanoparticles. Angewandte Chemie International Edition, 2010. 49(31): p. 5310-5314.
29. Mousavi, S., et al., Modification of the epoxy resin mechanical and thermal properties with silicon acrylate and montmorillonite nanoparticles. Polymers from Renewable Resources, 2016. 7(3): p. 101-113.
30. Dong, Y., et al., Polyamine-functionalized carbon quantum dots as fluorescent probes for selective and sensitive detection of copper ions. Analytical chemistry, 2012. 84(14): p. 6220-6224.
31. Mousavi, S.M., et al., Asymmetric membranes: a potential scaffold for wound healing applications. Symmetry, 2020. 12(7): p. 1100.
32. Dong, Y., et al., Polyamine-functionalized carbon quantum dots for chemical sensing. Carbon, 2012. 50(8): p. 2810-2815.
33. Mousavi, S., et al., Improved morphology and properties of nanocomposites, linear low density polyethylene, ethylene-co-vinyl acetate and nano clay particles by electron beam. Polymers from Renewable Resources, 2016. 7(4): p. 135-153.
34. Xu, Y., et al., Reduced carbon dots versus oxidized carbon dots: photo‐and electrochemiluminescence investigations for selected applications. Chemistry–A European Journal, 2013. 19(20): p. 6282-6288.
35. Mousavi, S.M., et al., Green synthesis of supermagnetic Fe3O4–MgO nanoparticles via Nutmeg essential oil toward superior anti-bacterial and anti-fungal performance. Journal of Drug Delivery Science and Technology, 2019. 54: p. 101352.
36. Deng, Y., et al., Long lifetime pure organic phosphorescence based on water soluble carbon dots. Chemical communications, 2013. 49(51): p. 5751-5753.
37. Mousavi, S., et al., Biodegradation study of nanocomposites of phenol novolac epoxy/unsaturated polyester resin/egg shell nanoparticles using natural polymers. Journal of Materials, 2015. 2015: p. 1-6.
38. Hashemi, S.A. and S.M. Mousavi, Effect of bubble based degradation on the physical properties of Single Wall Carbon Nanotube/Epoxy Resin composite and new approach in bubbles reduction. Composites Part A: Applied Science and Manufacturing, 2016. 90: p. 457-469.
39. Zhao, Q.-L., et al., Facile preparation of low cytotoxicity fluorescent carbon nanocrystals by electrooxidation of graphite. Chemical Communications, 2008(41): p. 5116-5118.
40. Mousavi, S., M. Zarei, and S. Hashemi, Polydopamine for biomedical application and drug delivery system. Med Chem (Los Angeles), 2018. 8: p. 218-29.
41. Sun, Y.-P., et al., Quantum-sized carbon dots for bright and colorful photoluminescence. Journal of the American Chemical Society, 2006. 128(24): p. 7756-7757.
42. Mousavi, S.M., et al., Modification of phenol novolac epoxy resin and unsaturated polyester using sasobit and silica nanoparticles. Polymers from Renewable Resources, 2017. 8(3): p. 117-132.
43. Lu, S., et al., Synthesis of dual functional gallic-acid-based carbon dots for bioimaging and antitumor therapy. Biomaterials science, 2019. 7(8): p. 3258-3265.
44. Xue, B., et al., Photoluminescent lignin hybridized carbon quantum dots composites for bioimaging applications. International journal of biological macromolecules, 2019. 122: p. 954-961.
45. Ren, X., et al., Synthesis of N-doped micropore carbon quantum dots with high quantum yield and dual-wavelength photoluminescence emission from biomass for cellular imaging. Nanomaterials, 2019. 9(4): p. 495.
46. Qian, J., et al., Aconitic acid derived carbon dots: Conjugated interaction for the detection of folic acid and fluorescence targeted imaging of folate receptor overexpressed cancer cells. Sensors and Actuators B: Chemical, 2018. 262: p. 444-451.
47. Pandey, S., et al., Carbon dots functionalized gold nanorod mediated delivery of doxorubicin: tri-functional nano-worms for drug delivery, photothermal therapy and bioimaging. Journal of Materials Chemistry B, 2013. 1(38): p. 4972-4982.
48. Hola, K., et al., Carbon dots—Emerging light emitters for bioimaging, cancer therapy and optoelectronics. Nano Today, 2014. 9(5): p. 590-603.
49. Amani, A.M., et al., Electric field induced alignment of carbon nanotubes: methodology and outcomes, in Carbon nanotubes-recent progress. 2017, IntechOpen.
50. Mousavi, S.M., et al., Data on cytotoxic and antibacterial activity of synthesized Fe3O4 nanoparticles using Malva sylvestris. Data in brief, 2020. 28: p. 104929.
51. Mousavi, S.M., et al., Synthesis of Fe3O4 nanoparticles modified by oak shell for treatment of wastewater containing Ni (II). Acta Chimica Slovenica, 2018. 65(3): p. 750-756.
52. Tang, J., et al., Carbon nanodots featuring efficient FRET for real‐time monitoring of drug delivery and two‐photon imaging. Advanced materials, 2013. 25(45): p. 6569-6574.
53. Mousavi, M., et al., Erythrosine adsorption from aqueous solution via decorated graphene oxide with magnetic iron oxide nano particles: kinetic and equilibrium studies. Acta Chimica Slovenica, 2018. 65(4): p. 882-894.
54. El-Shabasy, R.M., et al., Recent developments in carbon quantum dots: properties, fabrication techniques, and bio-applications. Processes, 2021. 9(2): p. 388.
55. Zhu, S., et al., Highly photoluminescent carbon dots for multicolor patterning, sensors, and bioimaging. Angewandte Chemie, 2013. 125(14): p. 4045-4049.
56. Hoan, B.T., P.D. Tam, and V.-H. Pham, Green synthesis of highly luminescent carbon quantum dots from lemon juice. Journal of Nanotechnology, 2019. 2019.
57. da Silva Júnior, A.H., et al., Novel carbon dots for zinc sensing from Campomanesia phaea. Materials Letters, 2021. 283: p. 128813.
58. Lai, Z., et al., Green synthesis of fluorescent carbon dots from cherry tomatoes for highly effective detection of trifluralin herbicide in soil samples. ChemistrySelect, 2020. 5(6): p. 1956-1960.
59. Wang, C., et al., Facile synthesis of novel carbon quantum dots from biomass waste for highly sensitive detection of iron ions. Materials Research Bulletin, 2020. 124: p. 110730.
60. Arumugam, N. and J. Kim, Synthesis of carbon quantum dots from Broccoli and their ability to detect silver ions. Materials Letters, 2018. 219: p. 37-40.
Published
2022-06-20
How to Cite
1.
Yari Kalashgrani M, Fallahi Nejad F, Rahmanian V. Carbon Quantum Dots Platforms: as nano therapeutic for Biomedical Applications. AANBT [Internet]. 20Jun.2022 [cited 25Apr.2024];3(2):38-2. Available from: https://www.dormaj.org/index.php/AANBT/article/view/562