Attenuating effect of polyalthia longifolia on cadmium sulfate- induced testicular toxicity

  • Ogunbiyi Olubunmi E Department of Anatomy, Faculty of Basic Medical Sciences, Colleges of Health Sciences, Babcock University, IIishan-Remo, Nigeria
  • Oyewopo Adeoye Oyetunji Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria
  • Tokunbo Olorunfemi S Department of Anatomy, Faculty of Basic Medical Sciences, Osun State University, Osogbo, Nigeria
  • Adeleke Opeyemi Samson Department of Anatomy, Faculty of Basic Medical Sciences, Osun State University, Osogbo, Nigeria
  • Abayomi Taiwo Adekemi Department of Anatomy, Faculty of Basic Medical Sciences, Osun State University, Osogbo, Nigeria
  • Johnson Olawumi Feyisike Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria
  • Bello Matthew K. Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ilorin, Nigeria
Keywords: Cadmium Sulfate, Testis, Histology, Immunohistochemistry, Semen analysis

Abstract

Polyalthia longifolia extract has numerous beneficial effects on human health. They have been reported to have antiviral, anti-allergic, anti-inflammatory, anti-tumour and antioxidant activities. Cadmium is used in the production of nickel cadmium batteries, pigments ceramics, plastic stabilizers, and fertilizers. Cigarette smoke is one of the most important sources of cadmium exposure in the general non-occupationally exposed population. In nonsmokers, the main source of cadmium is food, particularly cereals such as rice and wheat, green leafy vegetables, potato, and offal products such as liver and kidney. Twenty male Wistar rats were divided into four groups. Group A were orally treated with distilled water for twenty eight days, Group B were intraperitoneal treated with cadmium sulfate for three days and sacrificed twenty four hours later, Group C received oral administration of Polyalthia longifolia for twenty eight days and Group D received cadmium sulfate intraperitoneally for three days and post treated orally with Polyalthia longifolia for twenty five days. On the 29th day the animals were sacrificed through cervical dislocation, the right testis was excised and processed histologically, while the left testis was processed for semen analysis. The histological observation showed that Polyalthia longifolia administration improved the histoarchitectural distortion of the testis in the cadmium sulphate treated group. Polyalthia longifolia administration restored the alteration on the sperm parameters of the damaged testes. The result suggested that Polyalthia longifolia restored testicular toxicity induced by cadmium sulphate and may be used as sub fertility drug.

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Published
2021-05-03
How to Cite
Olubunmi E, O., Adeoye Oyetunji, O., Olorunfemi S, T., Opeyemi Samson, A., Taiwo Adekemi, A., Olawumi Feyisike, J., & Matthew K., B. (2021). Attenuating effect of polyalthia longifolia on cadmium sulfate- induced testicular toxicity. Journal of Infertility and Reproductive Biology, 9(2), 52-58. https://doi.org/10.47277/JIRB/9(1)/52
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