Effect of Tobacco Usage Through Smoking, Chewing, Environmental/Secondhand Tobacco Smoke on Human Reproduction, Pregnancy, or its Outcome-A Descriptive Overview

  • Sunil Kumar A-10, Radhey kunj Apartment, B/h Circuit house, Shahi Baugh, Ahmedabad-38 00 04, India (1Former, Director I/C, National Institute of Occupational Health (ICMR), Ahmedabad, India)
Keywords: Tobacco Smoking, Semen quality, Pregnancy Outcome, Smokeless Tobacco, Secondhand Smoke

Abstract

Humans are exposed to tobacco smoke and various tobacco related components while smoking, chewing, or through environmental/secondhand tobacco smoke etc. Tobacco usage causes huge mortality and morbidity. The literature was collected through searching the internet using various keywords and appropriate articles were included. The impact of tobacco smoking, chewing, or environmental/secondhand tobacco smoke on reproductive health and pregnancy outcome is summarized in this overview. Based upon data available, tobacco smoking might relate to erectile dysfunction, deterioration of semen quality, sperm DNA damage, impairment of hormones production and circulation, fertility potential impairment, in male and male-mediated hostile birth outcomes. While data on other forms of tobacco usage with regards to semen quality/ male reproduction is less documented than smoking. The data on females insinuated that tobacco usage affects the mensuration cycle, sexual pleasure, hormone production and release, fertility potential, etc. Prenatal tobacco exposure affects the pregnancy or outcome, birth weight, developmental parameters, menarche, puberty age, etc. In conclusion, the data available suggest that tobacco usage in any manner is harmful to the reproductive health of both sexes and affect pregnancy outcome.

Downloads

Download data is not yet available.

References

CDC, USA (2020). Centre for disease control and prevention. Electronic cigarettes. What the bottom line. https://www.cdc.gov/tobacco/basic_information/e-cigarettes/about-e-cigarettes.html. Retrieved Feb 24, 2021.

WHO (2020). Tobacco. Key facts https://www.who.int/news-room/fact-sheets/detail/tobacco. Retrieved Feb 25, 2021.

CDC, USA, Substance use during pregnancy-Tobacco. Content source, Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion July 2020. https://www.cdc.gov/reproductivehealth/ maternalinfanthealth/ substance-abuse/substance-abuse-during-pregnancy.htm. Assessed on Feb 24, 2021.

Dechanet C, Anahory T, Mathieu Daude JC, et al. Effects of cigarette smoking on reproduction. Human Reproduction Update. 2011; 17 (1): 76–95. doi.org/10.1093/ humupd /dmq 033.

Sadeu JC, Hughes CL, Agarwal S, Foster WG. Alcohol, drugs, caffeine, tobacco, and environmental contaminant exposure: Reproductive health consequences and clinical implications. Critical Reviews Toxicology. 2010; 40 (7): 633–652. doi: 10.3109 /10408444.2010.493552.

Jeremy JY, Mikhailidis DP. Cigarette smoking and erectile dysfunction. Journal of the Royal Society for the Promotion of Health. 1998;118 (3): 151-155. doi: 10.1177/ 146642409811800305

McVary KT, Carrier S, Wessells H, Subcommittee on smoking and erectile dysfunction socioeconomic committee, Sexual Medicine Society of North America. Smoking and erectile dysfunction: evidence-based analysis. Journal of Urology. 2001;166 (5):1624-1632.

Cao S, Gan Y, Dong X, et al. Association of quantity and duration of smoking with erectile dysfunction: a dose-response meta-analysis. Journal of Sexual Medicine. 2014; 11(10): 2376-2384. doi: 10.1111/jsm.12641

Biebel MG, Burnett AL, Sadeghi-Nejad H. Male sexual function and smoking. Sexual Medicine Reviews. 2016; 4(4):366-375. doi: 10.1016/j.sxmr.2016.05.001.

Kupelian V, Link CL, McKinlay JB. Association between smoking, passive smoking, and erectile dysfunction: results from the Boston Area Community Health (BACH) survey. European Urology. 2007; 52(2): 416-422. doi: 10.1016/j.eururo.2007.03.015

Millett C, Wen LM, Rissel C, et al. Smoking and erectile dysfunction: findings from a representative sample of Australian men. Tobacco Control. 2006;15 (2):136-139. doi: 10.1136/tc.2005.015545

He J, Reynolds K, Chen J, Chen CS, Wu X, Duan X, et al. Cigarette smoking and erectile dysfunction among Chinese men without clinical vascular disease. American Journal of Epidemiology. 2007;166(7): 803-809. doi: 10.1093/aje/kwm 154

Weber MF, Smith DP, O'Connell DL, et al. Risk factors for erectile dysfunction in a cohort of 108 477 Australian men. Medical Journal of Australia. 2013; 199 (2): 107-111. doi: 10.5694/mja12.11548.

Tostes RC, Carneiro FS, Lee AJ, et al. Cigarette smoking and erectile dysfunction: Focus on NO bioavailability and ROS generation. Journal of Sexual Medicine. 2008; 5(6): 1284–1295. doi: 10.1111/j.1743-6109.2008. 00804.x

Verze P, Margreiter M, Esposito K, et al. The link between cigarette smoking and erectile dysfunction: A systematic review. European Urology Focus. 2015; 1 (1): 39-46. doi: 10.1016/j.euf.2015.01.003.

Pourmand G, Alidaee MR, Rasuli S, et al. Do cigarette smokers with erectile dysfunction benefit from stopping? A prospective study. BJU International. 2004; 94(9):1310-1313. doi: 10.1111/j.1464-410X.2004. 05162.x

Vine MF, Tse Chiu-Kit J, Hu Ping-Chuan, Truong KY. Cigarette smoking and semen quality. Fertility Sterility.1966; 66 (4): 835-842. doi: 10.1016/s0015-0282(16)58223-5

Gaur DS, Talekar M, Pathak VP. Effect of cigarette smoking on semen quality of infertile men. Singapore Medical Journal. 2007; 48 (2): 119-123.

Parameswari R, Sridharan TB. Cigarette smoking and its toxicological overview on human male fertility—a prospective review. Toxin Reviews. 2021; 40 (2): 145-161. doi 10.1080/15569543.2019.1579229

Rehman R, Zahid N, Amjad S, et al. Relationship between smoking habit and sperm parameters among patients attending an infertility clinic. Frontiers in Physiology. 2019; 10: 1356. doi: 10.3389/fphys. 2019. 01356.

Mathur S, Jawad K, Dayal S. Effect of smoking and alcohol consumption on reproductive hormones and semen parameters in male partners of infertile couples. International Journal of Contemporary Medical Research. 2019; 6(9): I5-I9. doi.org/10.21276/ ijcmr. 2019.6.9.36

Chia SE, Ong CN, Tsakok FM. Effects of cigarette smoking on human semen quality. Archives of Andrology. 1994; 33(3):163-168. doi.org/10.3109/ 01485019408987820

Ramlau-Hansen CH, Aggerholm AS, Jensen MS, et al. Is smoking a risk factor for decreased semen quality? A cross-sectional analysis. Human Reproduction. 2007; 22 (1):188–196. doi.org/10.1093/humrep/del364

Asare-Anane H, Bannison SB, Ofori EK, et al. Tobacco smoking is associated with decreased semen quality. Reproductive Health. 2016; 13: 90. doi.org/10. 1186/ s12978-016-0207-z

Dai Jing-Bo, Wang Zhao-Xia, Qiao Zhong-Dong. The hazardous effects of tobacco smoking on male fertility. Asian Journal of Andrology. 2015;17(6):954-960 doi: 10.4103/1008-682X.150847.

Kumar Sunil, Murarka S, Mishra VV, Gautam AK. Environmental and lifestyle factors in deterioration of male reproductive health. Indian Journal of Medical Research. 2014; 140 (suppl S1): 29-35. http://www.ijmr.org.in/text. asp?2014/140/7/29/151079.

Tang Q, Pan F, Wu X, et al. Semen quality and cigarette smoking in a cohort of healthy fertile men. Environmental Epidemiology. 2019; 3(4): e055. doi: 10.1097/EE9.0000000000000055.

Pasqualotto FF, Sobreiro BP, Hallak J, et al. Cigarette smoking is related to a decrease in semen volume in a population of fertile men. BJU International. 2006; 97(2):324-326. doi: 10.1111/j.1464-410X.2005. 05906.x

Bundhun PK, Janoo G, Bhurtu A, et al. Tobacco smoking and semen quality in infertile males: a systematic review and meta-analysis. BMC Public Health. 2019; 19: 36.doi:10.1186/s12889-018-6319-3.

Sharma Reecha, Harlev Avi, Agarwal A, Esteves SC. Cigarette smoking and semen quality: A new meta-analysis examining the effect of the 2010 World Health Organization laboratory methods for the examination of human semen. European Urology. 2016; 70 (4): 635-645. doi: 10.1016/j.eururo.2016.04.010.

Yang F, Li L, Chen Jian-Ping, et al. Couple’s infertility in relation to male smoking in a Chinese rural area. Asian Journal of Andrology. 2017; 19: 311–315. doi: 10.4103/1008-682X.168685.

Sapra KJ, Dana Barr D, Maisog JM, et al. Time-to-pregnancy associated with couples’ use of tobacco products. Nicotine & Tobacco Research. 2016; 18(11): 2154–2161. doi: 10.1093/ntr/ ntw132.

Shrivastava V, Marmor H, Chernyak S, et al. Cigarette smoke affects post translational modifications and inhibits capacitation-induced changes in human sperm proteins. Reproductive Toxicology. 2014; 43: 125-129. doi: 10.1016/j.reprotox.2013.12.001

Axelsson J, Sabra S, Rylander L, et al. Association between paternal smoking at the time of pregnancy and the semen quality in sons. PLoS One. 2018 Nov 21,13(11):e0207221 doi.org/10.1371/journal. pone.0207221

Axelsson J, Rylander L, Rignell-Hydbom A, et al. The impact of paternal and maternal smoking on semen quality of adolescent men. PLoS One. 2013; 8(6): e66766. doi.org/10.1371/journal. pone.0066766.

Beal MA, Yauk CL, Marchetti F. From sperm to offspring: Assessing the heritable genetic consequences of paternal smoking and potential public health impacts. Mutation Research. 2017; 773: 26-50. doi: 10.1016/j.mrrev.2017.04.001

Wang L, Yang Y, Liu F, et al. Paternal smoking, and spontaneous abortion: a population-based retrospective cohort study among non-smoking women aged 20–49 years in rural China. The Journal of Epidemiology and Community Health. 2018; 72 (9): 783-789. doi: 10.1136/jech-2017-210311

Jensen MS, Mabeck LM, Toft G, et al. Lower sperm counts following prenatal tobacco exposure. Human Reproduction. 2005; 20(9); 2559–2566. doi.org/10.1093/humrep/dei110.

Sieminska A, Jassem E. The many faces of tobacco use among women. Medical Science Monitor. 2014; 20:153-162. doi: 10.12659/MSM.889796.

WHO. (2010). Gender, women, and the tobacco epidemic: 4. Impact of tobacco use on women’s health. pp 51-63.https://www.who.int/tobacco/publications/gender/en_tfi_gender_women_impact_tobacco_use_ women_health.pdf. Retrieved on Feb 24, 2021.

Wen Li M, Rissel C, Cheng Y, et al. Tobacco smoking, and sexual difficulties among Australian adults: a cross-sectional study. Sexual Health. 2017;14(4): 313-319. doi.org/10.1071/SH17005.

Choi J, Shin DW, Lee S, et al. Dose-response relationship between cigarette smoking and female sexual dysfunction. Obstetrics & Gynecology Science. 2015; 58(4):302-308. doi: 10.5468/ogs.2015.58.4.302

Yilmaz MO, Akin Y, Gulum M, et al. Relationship between smoking and female sexual dysfunction. Andrology (Los Angel). 2015; 4:144. doi:10.4172/2167-0250.1000144.

Safarinejad MR. Female sexual dysfunction in a population-based study in Iran: prevalence and associated risk factors. International Journal of Impotence Research. 2006;18(4):382-395. doi: 10.1038/sj.ijir.3901440

Jaafarpour M, Khani A, Khajavikhan J, Suhrabi Z. Female sexual dysfunction: prevalence and risk factors. Journal of Clinical and Diagnostic Research. 2013; 7(12): 2877-2880. doi: 10.7860/JCDR/2013/6813.3822.

Costa RM, Peres L. Smoking is unrelated to female sexual function. Substance Use & Misuse. 2015; 50 (2):189-194. doi: 10.3109/10826084.2014.962054.

Windham GC, Elkin EP, Swan SH, et al. Cigarette smoking and effects on menstrual function. Obstetrics & Gynecology. 1999; 93(1):59-65. doi: 10.1016/s0029-7844(98)00317-2

Windham GC, Bottomley C, Birner C, Fenster L. Age at menarche in relation to maternal use of tobacco, alcohol, coffee, and tea during pregnancy. American Journal of Epidemiology. 2004;159 (9): 862–871. https://doi. org/10.1093/aje/kwh117

Windham GC, Mitchell P, Anderson M, Lasley BL. Cigarette smoking and effects on hormone function in premenopausal women. Environmental Health Perspectives. 2005; 113 (10):1285-1290. doi: 10.1289 /ehp. 7899.

Rowland AS, Baird DD, Long S, et al. Influence of medical conditions and lifestyle factors on menstrual cycle. Epidemiology. 2002; 13 (6): 668-674. doi: 10.1097/00001648-200211000-00011

Kaufman DW, Slone D, Rosenberg L, et al. Cigarette smoking and age at natural menopause. American Journal of Public Health. 1980; 70(4): 420–422. doi: 10.2105/ajph.70.4.420.

Oboni Jean-Baptiste, Marques-Vidal Pedro, Bastardot François, et al. Impact of smoking on fertility and age of menopause: a population-based assessment. BMJ Open. 2016; 6(11): e012015. doi: 10.1136/ bmjopen-2016-012015.

Yang HJ, Suh PS, Kim SJ, Lee SY. Effects of smoking on menopausal age: Results from the Korea national health and nutrition examination survey, 2007 to 2012. Journal of Preventive Medicine & Public Health. 2015; 48(4): 216–224. doi: 10.3961/ jpmph.15.021.

Zhu D, Chung Hsin-Fang, Pandeya Nirmala, et al. Relationships between intensity, duration, cumulative dose, and timing of smoking with age at menopause: A pooled analysis of individual data from 17 observational studies. PLoS Medicine. 2018; 15(11): e1002704. doi: 10.1371/ journal. pmed.1002704.

Whitcomb BW, Purdue-Smithe AC, Szegda KL, et al. Cigarette smoking and risk of early natural menopause. American Journal of Epidemiology. 2018;187(4):696-704. doi: 10.1093/aje/ kwx292.

WHO (2014), Women and Tobacco use. http://applications.emro.who.int/docs/ Fact_Sheet_TFI _2014_EN_15320.pdf?ua=1

Krstev S, Marinković J, Simić S, et al. The influence of maternal smoking and exposure to residential ETS on pregnancy outcomes: a retrospective national study. Maternal and Child Health Journal. 2013;17(9):1591-1598. doi: 10.1007/s10995-012-1169-6.

Herman HG, Miremberg H, Nini N, et al. The effects of maternal smoking on pregnancy outcome and placental histopathology lesions. Reproductive Toxicology, 2016; 65: 24-28. doi.org/10.1016/j.reprotox. 2016.05.022.

Ko Ting-Jung, Tsai Li-Yi, Chu Li-Ching, et al. Parental smoking during pregnancy and its association with low birth weight, small for gestational age, and preterm birth offspring: A birth cohort study. Pediatrics & Neonatology. 2014; 55 (1): 20-27. doi: 10.1016/j.pedneo.2013.05.005

Lin Yuh-Jyh. Low birth weight, preterm births, and intrauterine growth retardation in relation to parental smoking during pregnancy. Pediatrics & Neonatology. 2014; 55 (1): 3-4. doi.org/10.1016/j. pedneo. 2013.09.014

Ernst A, Kristensen SL, Toft G, et al. Maternal smoking during pregnancy and reproductive health of daughters: a follow-up study spanning two decades. Human Reproduction. 2012; 27(12): 3593-3600. doi: 10.1093/humrep/des337.

Yermachenko A, Dvornyk V. A meta-analysis provides evidence that prenatal smoking exposure decreases age at menarche. Reproductive Toxicology. 2015; 58: 222-228. doi: 10.1016/j.reprotox.2015.10.019.

Behie AM, O'Donnell MH. Prenatal smoking and age at menarche: influence of the prenatal environment on the timing of puberty. Human Reproduction. 2015; 30(4):957-962. doi: 10.1093/humrep/dev033.

Houghton LC, Goldberg M, Wei Y, et al. Why do studies show different associations between intrauterine exposure to maternal smoking and age at menarche? Annals of Epidemiology. 2018; 28(3):197-203. doi: 10.1016/j.annepidem.2018.01.004.

Chen Y, Liu Q, Li W, et al. Association of prenatal and childhood environment smoking exposure with puberty timing: a systematic review and meta-analysis. Environmental Health and Preventive Medicine. 2018; 23(1):33. doi: 10.1186/s 12199-018-0722-3.

Brix N, Ernst A, Lauridsen LLB, et al. Maternal smoking during pregnancy and timing of puberty in sons and daughters: A population-based cohort study. American Journal of Epidemiology. 2019;188 (1): 47-56. doi: 10.1093/aje/kwy206.

Shrestha A, Nohr EA, Bech BH, et al. Smoking and alcohol use during pregnancy and age of menarche in daughters. Human Reproduction. 2011; 26 (1): 259–265. doi: 10.1093/humrep/ deq 316

Pineles BL, Park E, Samet JM. Systematic review and meta-analysis of miscarriage and maternal exposure to tobacco smoke during pregnancy. American Journal of Epidemiology. 2014;179 (7): 807–823. https://doi. org/10.1093/aje/kwt334.

Pineles BL, Hsu S, Park E, Samet JM. Systematic review and meta-analyses of perinatal death and maternal exposure to tobacco smoke during pregnancy. American Journal of Epidemiology. 2016;184(2): 87-97. doi: 10.1093/aje/kwv301.

Kharkova OA, Grjibovski AM, Krettek A, et al. Effect of smoking behavior before and during pregnancy on selected birth outcomes among singleton full-term pregnancy: A murmansk county birth registry study. International Journal of Environmental Research and Public Health. 2017;14(8). pii: E867. doi: 10.3390/ ijerph14080867.

Steyn K, de Wet T, Saloojee Y, et al. The influence of maternal cigarette smoking, snuff use and passive smoking on pregnancy outcomes: The birth to ten Study. Paediatric and Perinatal Epidemiology. 2006; 20(2): 90-99. doi: 10.1111/j.1365-3016. 2006.00707.x

Hrubá D, Kachlík P. Influence of maternal active and passive smoking during pregnancy on birthweight in newborns. Central European Journal of Public Health. 2000; 8 (4): 249-252. PMID: 11125982

Sobinoff AP, Sutherland JM, Beckett EL, et al. Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility. Human Reproduction. 2014; 29(12):2719-2735. doi: 10.1093/ humrep/ deu235.

Soares SR, Melo MA. Cigarette smoking and reproductive function. Current Opinion in Obstetrics and Gynecology. 2008; 20(3): 281-91. doi: 10.1097/GCO. 0b013e3282fc9c1e.

Heger Anna, Sator M, Walch K, Pietrowski D. Smoking decreases endometrial thickness in IVF/ICSI patients. Geburtshilfe und Frauenheilkunde. 2018; 78 (1): 78-82. doi: 10.1055/ s-0043-123762.

Fuentes A, Muñoz A, Barnhart K, et al. Recent cigarette smoking and assisted reproductive technologies outcome. Fertility Sterility, 2010; 93 (1): 89-95. doi: 10.1016/j.fertnstert. 2008.09.073

Neal MS, Hughes EG, Holloway AC, Foster WG. Side-stream smoking is equally as damaging as mainstream smoking on IVF outcomes. Human Reproduction. 2005; 20 (9): 2531-2535. https://doi.org/10.1093/humrep/ dei080

Cinar O, Dilbaz S, Terzioglu F, et al. Does cigarette smoking really have detrimental effects on outcomes of IVF ?. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2014; 174:106-110. doi: 10.1016/j.ejogrb. 2013. 12.026.

Wright KP, Trimarchi JR, Allsworth J, Keefe D. The effect of female tobacco smoking on IVF outcomes. Human Reproduction. 2006; 21 (11): 2930–2934. https://doi.org/ 10.1093/humrep/del269.

Freour T, Masson D, Mirallie S, et al. Active smoking compromises IVF outcome and affects ovarian reserve. Reproductive Biomedicine Online.2008; 16 (1): 96-102. doi: 10.1016/s1472-6483(10)60561-5.

Zitzmann M, Rolf C, Nordhoff V, et al. Male smokers have a decreased success rate for in vitro fertilization and intracytoplasmic sperm injection. Fertility Sterility. 2003; 79 (Suppl. 3): 1550-1554. doi: 10.1016/s0015-0282(03)00339-x

Benedict MD, Missmer SA, Vahratian A, et al. Secondhand tobacco smoke exposure is associated with increased risk of failed implantation and reduced IVF success. Human Reproduction. 2011; 26 (9): 2525-2531. https://doi.org/10.1093/ humrep/ der226

Oral Health Foundation, UK. Smokeless tobacco. https://www.dentalhealth. org/smokeless tobacco. Retrieved 9th Jan 2021.

Pednekar MS and Gangadharan P. Smokeless tobacco and all-cause mortality. In smokeless tobacco and public health in India. Ministry of Health & Family Welfare, Govt of India; New Delhi; Gupta PC, Arora M, Sinha DN, Asma S, Parascandola M (eds.) pp 165-171, 2016

Kumar S, Nigam SK, Shaikh SA, Saiyed HN. Effect of pan masala on sperm morphology of a mouse. Bulletin of Environmental Contamination and Toxicology. 2003; 70 (6): 1184-1188. doi.org/10.1007/s00128-003-0107-0

Kumari Archana, Mojidra BN, Gautam AK, et al. Reproductive toxic potential of panmasala in male Swiss albino mice. Toxicology and Industrial Health, 2011; 27 (8): 683-690. doi: 10.1177/0748233710395344

Kumari Archana, Gautam AK, Lakkad BC, Kumar Sunil. In utero and lactation exposure of mice to panmasala: Effect on dams and pregnancy outcome. Journal of Environmental Pathology, Toxicology, and Oncology. 2011; 30 (1): 71-81. doi: 10.1615/ jenvironpathol toxicol oncol. v30.i1. 70

Kumar Sunil. Tobacco and areca nut chewing--reproductive impairments: an overview. Reproductive Toxicology. 2013; 36:12-17. doi: 10.1016/j.reprotox. 2012.11.007.

Said TM, Ranga G, Agarwal A. Relationship between semen quality and tobacco chewing in men undergoing infertility evaluation. Fertility Sterility. 2005; 84(3):649-653. doi: 10.1016/j.fertnstert. 2005.03.052

Ratsch A, Bogossian F. Smokeless tobacco use in pregnancy: an integrative review of the literature. International Journal of Public Health. 2014; 59(4): 599-608. doi: 10.1007/s00038-014-0558-6.

England LJ, Kim SY, Shapiro-Mendoza CK, et al. Maternal smokeless tobacco uses in Alaska native women and singleton infant birth size. Acta Obstetricia et Gynecologica Scandinavica. 2012; 91(1):93-103. doi: 10.1111/j.1600-0412.2011.01273. x.

Gupta PC, Subramoney S. Smokeless tobacco use and risk of stillbirth: a cohort study in Mumbai, India. Epidemiology. 2006;17(1):47-51. doi: 10.1097/01.ede. 0000 190545. 19168.c4

Sunanda P, Panda B, Dash C, et al. Prevalence of abnormal spermatozoa in tobacco chewing sub-fertile males. Journal of Human Reproductive Sciences. 2014; 7(2): 136–142. doi: 10.4103/0974-1208.138873

Sharma S, Gandhi P, Kaur M, Kota K. The effect of tobacco consumption on semen quality of men undergoing infertility evaluation. Journal of Advanced Medical and Dental Sciences Research. 2019; 7(6): 98-10. doi:10.21276/jamdsr.

Juárez SP, Merlo J. The effect of Swedish snuff (snus) on offspring birthweight: a sibling analysis. PLoS One. 2013; 8(6):e65611. doi: 10.1371/journal.pone.0065611.

Aziz Ali S, Khan U, Abrejo F, et al. Use of smokeless tobacco before conception and its relationship with maternal and fetal outcomes of pregnancy in Thatta, Pakistan: Findings from women first study. Nicotine Tobacco Research. 2021;23(8):1291-1299. doi: 10.1093/ntr/ntaa215.

Misra DP, Nguyen RH. Environmental tobacco smoke and low birth weight: a hazard in the workplace. Environmental Health Perspectives. 1999; 107 (Suppl 6): 897-904. https://doi.org/10.1289/ehp.99107s6897.

Lindbohm ML, Sallmén M, Taskinen H. Effects of exposure to environmental tobacco smoke on reproductive health. Scandinavian Journal of Work, Environment & Health. 2002; 28 (Suppl 2): 84-96. PMID 12058806

Leonardi-Bee JO, Britton J, Venn A. Secondhand smoke, and adverse fetal outcomes in nonsmoking pregnant women: A meta-analysis. Pediatrics. 2011; 127 (4): 734-741. https://doi.org/10.1542/peds.2010-3041

Crane JM, Keough M, Murphy P, et al. Effects of environmental tobacco smoke on perinatal outcomes: a retrospective cohort study. BJOG: An International Journal of Obstetrics & Gynaecology. 2011; 118 (7): 865-871. doi: 10.1111/j.1471-0528.2011.02941. x.

Pathirathna ML, Abeywickrama HM, Sekijima K, et al. Effects of prenatal tobacco and wood-fuel smoke exposure on birth weight in Sri Lanka. Healthcare (Basel). 2017; 5(4) pii: E64. doi: 10.3390/healthcare 5040064.

Ion RC, Wills AK, Bernal AL. Environmental tobacco smoke exposure in pregnancy is associated with earlier delivery and reduced birth weight. Reproductive Sciences. 2015; 22(12):1603-1611. doi: 10. 1177/1933719115 612135.

Meeker JD, Missmer SA, Cramer DW, Hauser R. Maternal exposure to second-hand tobacco smoke and pregnancy outcome among couples undergoing assisted reproduction. Human Reproduction. 2007; 22(2):337-345. doi: 10.1093/ humrep/del406

Athamneh T, Qudah S, Mashaqbeh M, et al. Passive smoking, and pregnancy outcome. Middle East Journal of Family Medicine. 2015; 13 (2): 34-38. doi:10.5742/MEWFM.2015.92675.

Hoyt AT, Canfield MA, Romitti PA, et al. Does maternal exposure to secondhand tobacco smoke during pregnancy increase the risk for preterm or small-for-gestational age birth? Maternal and Child Health Journal. 2018; 22(10):1418-1429. doi: 10.1007/s10995-018-2522-1.

Subramoney S, d'Espaignet ET, Gupta PC. Higher risk of stillbirth among lower- and middle-income women who do not use tobacco but live with smokers. Acta Obstetricia et Gynecologica Scandinavica. 2010; 89 (4):572-577. doi: 10.3109/ 0001634100380 1656.

Hoyt AT, Canfield MA, Romitti PA, et al. Associations between maternal periconceptional exposure to secondhand tobacco smoke and major birth defects. American Journal of Obstetrics and Gynecology. 2016; 215 (5): 613.e1-613.e11. doi: 10.1016/j.ajog. 2016.07.022.

Pi X, Li Z, Jin L, et al. Secondhand smoke during the periconceptional period increases the risk for orofacial clefts in offspring. Paediatric and Perinatal Epidemiology. 2018; 32(5): 423-427. doi: 10.1111/ppe. 12497.

Wu F-Y, Isaac Wu H-D, Yang H-L, et al. Associations among genetic susceptibility, DNA damage, and pregnancy outcomes of expectant mothers exposed to environmental tobacco smoke. Science of the Total Environment. 2007; 386 (1–3): 124-133. doi: 10.1016/j.scitotenv. 2007. 06. 003

Nadhiroh Siti R, Djokosujono Kusharisupeni, Utari Diah Mulyawati. The association between secondhand smoke exposure and growth outcomes of children: A systematic literature review. Tobacco Induced Diseases. 2020; 18 (March):12. doi: https://doi.org/10.18332/tid/117958

La Maestra S, De Flora S, Micale RT. Does second-hand smoke affect semen quality? Archives of Toxicology. 2014; 88: 1187-1188. https://doi.org/10.1007/ s00204-014-1241-7.

Marchetti F, Rowan-Carroll A, Williams A, et al. Side stream tobacco smoke is a male germ cell mutagen. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108 (31): 12811-12814. https://doi. org/10.1073/pnas.1106896108.

Shenoy RD, Sindgikar SP, Shenoy V, et al. Pregnancy outcome in occupational tobacco exposure: A cohort study from south India. Indian Journal of Community Medicine. 2020; 45(1):54-59. doi: 10.4103/ijcm. IJCM_195_19.

Díez-Izquierdo Ana, Balaguer A, Lidon-Moyano C, et al. Correlation between tobacco control policies and preterm births and low birth weight in Europe. Environmental Research. 2018; 160: 547-553. doi: 10.1016/j.envres.2017.10.033

Published
2022-06-20
How to Cite
Kumar, S. (2022). Effect of Tobacco Usage Through Smoking, Chewing, Environmental/Secondhand Tobacco Smoke on Human Reproduction, Pregnancy, or its Outcome-A Descriptive Overview. Journal of Infertility and Reproductive Biology, 10(2), 28-40. https://doi.org/10.47277/JIRB/10(2)/28
Section
Regular publication process (free of charge)