https://www.dormaj.org/index.php/JIRB/issue/feed 2023-03-31T05:48:11-05:00 Dr. Sanaz Alaee jirb@dormaj.org Open Journal Systems <p><strong><span lang="EN-GB">Journal of Infertility and Reproductive Biology (JIRB)</span></strong></p> <p><strong><span lang="EN-GB">ISSN:</span></strong><span lang="EN-GB">&nbsp;2310-7588</span></p> <p style="text-align: justify;">Journal of Infertility and Reproductive Biology (JIRB) is a quarterly, peer-reviewed, open access, and free of charge journal that publishes original research articles as well as review articles in all areas of infertility and reproductive sciences. This journal was financed by&nbsp;<span class="SpellE">D</span><span class="SpellE">orma</span>&nbsp;Trading&nbsp;<span class="SpellE">Est</span>, publisher<a href="http://www.dormaj.com">,</a>&nbsp;Dubai, United Arab Emirates, and Jami Institute of Technology, Isfahan, Iran.&nbsp;JIRB is an Open Access Journal Database&nbsp;<span class="il">for</span>&nbsp;the high visibility and promotion of your articles. JIRB is steered by a distinguished&nbsp;<a href="https://dormaj.com/index.php/JIRB/about/editorialTeam">Board of Editors</a>&nbsp;and is supported by an international reviewer team consisting of prominent individuals representing many well-known universities, colleges, and corporations in Germany, Spain, Korea, India, Bangladesh, and many more.<strong>&nbsp;</strong>To maintain a high-quality journal, manuscripts that appear in the JIRB Articles section have been subjected to a rigorous review process. This includes blind reviews by three or more members of the international editorial review team, followed by a detailed review by the JIRB editors. The JIRB has been financially and scientifically supported by <a href="http://en.jamiuni.ir/">the Jami Institute of Technology</a>. The Journal welcomes original research contributions (previously unpublished) from all established areas of infertility and reproductive sciences.&nbsp;</p> https://www.dormaj.org/index.php/JIRB/article/view/580 2023-03-31T05:48:11-05:00 Sanjay Mishra sanjaymishra66@gmail.com Ritika Saxena ritikashrivastava88@gmail.com Amit Kumar Mani Tiwari manikgmc@gmail.com S. K. Chauhan rfraclko2015@gmail.com Priyanka Nayak priyankanov28@gmail.com

<p>Fertilization, an important phase of reproduction, is physiologically the union of the male and female gamete. This progression involves the fusion of an oocyte with a sperm, leading to generation of a single diploid cell, the zygote, from which a new individual organism develops. The elucidation of the physiological, biochemical and molecular mechanisms of fertilization has enthralled researchers of relevance for several years. This overview embodies this fascinating progression at physiological, biochemical and molecular level. A number of molecules have been recognized to play a key role in each step of this interesting process pertaining to the sperm magnetism from the oocyte, the sperm maturation, the sperm and oocyte union and the two gamete pronuclei fusion leading to the development of zygote. The compilation of data and salient hypotheses covered by this review provides new insights into perception of the causes of fertility issues due to fertilization disorders using the platform of <em>in-silico</em> studies.</p>

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