Journal of Infertility and Reproductive Biology <p><strong><span lang="EN-GB">Journal of Infertility and Reproductive Biology (JIRB)</span></strong></p> <p><strong><span lang="EN-GB">ISSN:</span></strong><span lang="EN-GB">&nbsp;2310-7588</span></p> <p>Journal of Infertility and Reproductive Biology (JIRB) is a quarterly, peer-reviewed, open access, and free of charge journal that publishes original research articles as well as review articles in all areas of infertility and reproductive sciences. This journal was financed by&nbsp;<span class="SpellE">D</span><span class="SpellE">orma</span>&nbsp;Trading&nbsp;<span class="SpellE">Est</span>, publisher<a href="">,</a>&nbsp;Dubai, United Arab Emirates, and Jami Institute of Technology, Isfahan, Iran.&nbsp;JIRB is an Open Access Journal Database&nbsp;<span class="il">for</span>&nbsp;the high visibility and promotion of your articles. JIRB is steered by a distinguished&nbsp;<a href="">Board of Editors</a>&nbsp;and is supported by an international reviewer team consisting of prominent individuals representing many well-known universities, colleges, and corporations in Germany, Spain, Korea, India, Bangladesh, and many more.<strong>&nbsp;</strong>To maintain a high-quality journal, manuscripts that appear in the JIRB Articles section have been subjected to a rigorous review process. This includes blind reviews by three or more members of the international editorial review team, followed by a detailed review by the JIRB editors. The Journal welcomes original research contributions (previously unpublished) from all established areas of infertility and reproductive sciences.&nbsp;</p> Dorma Journals en-US Journal of Infertility and Reproductive Biology 2310-7588 Emotional Stress Lowers Follicular Output Rate (FORT) of Unexplained Infertile or Poor Responder Women unlike Women with Male Infertility without any Prognostic Effect on Cycle Outcomes during Ovulation Induction for In Vitro Fertilization <p>A total of 78 patients have accepted to evaluate and answer questions in the Beck depression questionnaire form at the beginning of their controlled ovarian hyperstimulation procedures. Among these patients; 28 (36%), 27 (34%), and 23 (30%) of them were accepted for in vitro fertilization and embryo transfer (IVF-ET) treatment due to male factor, explained infertility and poor ovarian reserve respectively. Based on the Beck depression scale; 9 (12%) patients had mild depression, 31 (39%) patients had moderate depression and 38 (49%) patients had severe depression. IVF-ET cycle outcomes of these three groups of depression levels are statistically similar. A significant negative correlation between Beck depression scores a Follicular Output Rate (FORT) ratios, but not for metaphase II (MII) oocyte numbers, has been detected among unexplained infertile and poor ovarian reserve groups. A significant relationship between increasing Beck depression scores and lower FORT ratios have also been detected for unexplained infertile and poor ovarian reserve groups.&nbsp; FORT ratio which is achieved during the controlled ovarian hyperstimulation (COH) process of IVF-ET procedures seems to be lowered by emotional stress among unexplained or poor responder infertile women despite lack of a clinical effect on other cycle outcomes. Further studies investigating the effect of emotional stress itself and interventions to relieve this stress on IVF-ET cycle outcomes are needed to clarify this uncertainty<strong>.</strong></p> Serkan Kahyaoglu Pınar Gulsen Ozge Gurbuz Caner Kose Inci Kahyaoglu Hacer Cavidan Gulerman Nafiye Yılmaz Yaprak Ustun ##submission.copyrightStatement## 2021-08-26 2021-08-26 9 3 109 116 Longitudinal vs Horizontal Capsular Incision! Does it Alter Micro-TESE Outcome <p>Micro-TESE (Testicular Sperm Extraction), a procedure performed for treatment of Non-Obstructive Azoospermia, a leading infertility issue among males globally accounting for about 7% of the male population. Azoospermia is the absence of sperms in ejaculate upon semen analysis, 2% of the global population has encountered. A lot is discussed upon sperm retrieval success in both variants of Micro-TESE, which are Transverse or horizontal and longitudinal or vertical approaches, established studies have identified about 45% to 65% of success retrieving spermatozoa. The objective is the identification of the success of both the variants of procedure separately and also of postop complications to both approaches for micro-TESE. A cohort study, for which data, secondary (retrospective), was obtained from King Abdulaziz Medical City (KAMC), Riyadh. The time frame for data covered January 2016 to November 2018; 87 patients underwent micro-TESE, as in the logbook available in “Best Care System at KAMC. Data obtained was analyzed using SPSS Software, 87 of these patients who underwent micro-TESE procedure, 45 were done with the transverse approach and 42 with longitudinal approach, accounting for 51.7% and 48.3%, respectively. Upon postop evaluation, in the transverse approach, sperm were retrieved in 25.29% and for the longitudinal approach, retrieval was about 19.54%. The success rate was 48.9% out of 45 procedures in the transverse approach and 40.5% out of 42 procedures in the vertical/Longitudinal approach. The most common reported post-operative complication in transverse type was atrophy 20% and pain 13.3% on other hand common complications recorded for vertical type, atrophy was about 17.2% and pain in12.6% of patients. Not much statistical significance was observed between the transverse and longitudinal approach in either of the outcomes whether it is success rate or post-op complications. Both approaches are influenced by the factors of surgeon expertise and certain other factors that include pre and postop hormonal therapy, baseline hormonal status, and ICSI.</p> Hani Albadawe Rizwanul Haque Naif Alhifthi Abdullah Almousa Turki A Alferayan Khalid A Alrabeeah Saad M Abumelha ##submission.copyrightStatement## 2021-09-03 2021-09-03 9 3 117 122 Assessment of Fertility, Progesterone Profiles and Oxidative Stress Parameters after Estrus Induction and Artificial Insemination in Cows <p>Artificial insemination (AI) has been identified as a means to intensify local production and optimize the availability of proteins of animal origin in Africa. Some factors are seemingly responding to the failure of this application in rural areas. This study was conducted to evaluate the fertility, progesterone profiles, and oxidative stress parameters after estrus induction and artificial insemination in cows according to age, breeds, and body condition score after the implementation of two estrus synchronization protocols. The induction of estrus was realized using two protocols with each protocol corresponding to one group of cows. Oxidative stress parameters were studied by measuring the concentrations of malondialdehyde and superoxide dismutase. Protocol 1 was applied with CIDR+Cidirol-CIDR removal+Lutalyse+Cidirol-A, which resulted in a synchronization rate of 94.47%, and the second protocol with CIDR+Cidirol-CIDR removal+Lutalyse-IA+Cidirol (protocol 2), which gave an estrus rate of 70% and was significantly different from the first one (p &lt; 0.05). The overall success rate of artificial insemination recorded was 69.23%. With respect to the protocols, protocol 1 gave a significantly higher gestation rate (80%) compared to protocol 2 (50%). Fertility was affected by the breed, age, and body condition score (p &lt; 0.05). The later injection of the Cidirol (Day 9) in protocol 2 induced the lowest rate of fertility after artificial insemination. The present study also suggests that estrus synchronization methods and artificial insemination contribute to the variation of oxidative stress parameters such as malondialdehyde and superoxide dismutase which leads to an imbalance resulting in oxidative stress.</p> Hakoueu Flora Dinga Ndzi Elvis Ndukong Nsadzetsen Gilbert Adzemye Mbiba Hassanu Fanadzenyuy Kinso Ambrose Limnyuy Kouamo Justin Ngoula Ferdinand Bayemi Henri ##submission.copyrightStatement## 2021-09-20 2021-09-20 9 3 123 129 Dose-dependent Effect of Garlic (Allium Sativum) Extract feeding on Semen Characteristics and Testes in Wistar Rats <p><em>Allium sativum</em> (garlic) is widely used all over the world for the prevention and treatment of several diseases. However, the dose-dependent effect of garlic on the male reproductive system in apparently healthy subjects has not been sufficiently evaluated. The objective of the study was to determine the dose-dependent impact of aqueous extract of garlic on semen characteristics and testicular morphology in male Wistar rats. Twenty adult male Wistar rats were assigned into four groups of five rats in each group.. Group 1 (control) was given feed and water only, group 2 was given 500mg/kg body weight (BW) of <em>Allium sativum</em> extract, group 3 was given 750mg/kg BW of <em>Allium sativum</em> extract and group 4 received 1000mg/kg BW of <em>Allium sativum</em> extract. All groups were given feed and water ad libitum. The experiment lasted for 30 days after which the animals were sacrificed; the testis and epididymis were collected for laboratory analysis. The epididymis was homogenized in buffer, diluted, and analyzed microscopically. The data generated were compared using analysis of variance (ANOVA). Data showed that the administration of high concentrations of garlic caused teratozoospermia characterized by a poorly formed head, tailless sperm cells, and bent body with premature sperm cells. Histological findings also showed mild distortions in the shape of seminiferous tubules, congestions in interstitial blood vessels (suggestive of inflammation), slight reductions in size, and mildly thickened outlines of seminiferous tubules. Sperm progressive motility was significantly higher in the high dose group while no significant difference was observed in sperm count, morphology, viability, and pH. The consumption of high concentrations of&nbsp; <em>Allium sativum</em> may lead to adverse consequences on teratozoospermia and inflammation of the interstitial blood vessels in Wistar rats. Therefore, raw garlic should be consumed with caution as high concentrations may be deleterious to male reproductive health.</p> Mathias Abiodun Emokpae Olatunde Olaode ##submission.copyrightStatement## 2021-09-20 2021-09-20 9 3 130 135